After working as a modeller in pharma industry and later becoming a PhD in Systems Pharmacology and a Marie Curie - Tecniospring Postdoctoral Fellow, I am now a Sir Henry Wellcome PostDoctoral Fellow at the Institute of Cancer Research (ICR), Department of Data Science and Division of Cancer Therapeutics in London (UK), one of the best academic drug discovery centers worldwide. Having worked in industry and academia, I am interested translational research aiming to bridge applied industrial drug discovery with a much needed understanding of remaining fundamental questions in cancer chemical systems biology. To this aim, I have joined the ICR to perform the project "Harnessing polypharmacology in Cancer Therapeutics", aiming at identifying new targets of cancer drugs that qualify as biomarkers of exceptional patient response using in silico target profiling and data from Phase I clinical trials at the Royal Marsden Hospital. The ultimate aim of the project is to expand the uses of cancer drugs in selected patient populations and drug combinations. I also collaborate in the development of the knowledgebase canSAR and my interest in chemical probes has recently yielded Probe Miner, a website resource to help researchers objectively assess and select chemical probes for their target of interest using data science.This personal webpage aims to comprehensively collect all my research and publications, from papers to presentations and science dissemination activities. I will also try to regularly comment on the science I feel more close to. Welcome!
LONG TERM VIEW
In recent years, the 'omics' revolution has provided us an incredible ammount of data availiable through online resources. More recently, this 'omics' data is being complemented with pharmacological data. As a result, it is increasingly apparent that we don't fully understand how drugs work. We have now the oportunity to use 'omics' data in innovative ways to better understand the mechanism of action of drugs. Systems Pharmacology will help us to better use the drugs we have and develop better drugs for the future!